Abstract: Future changes in floods and water availability across China under representative concentration pathway 2.6 (RCP2.6) and RCP8.5 are studied by analyzing discharge simulations from the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP) with the consideration of uncertainties among global climate models (GCMs) and hydrologic models. Floods and water availability derived from ISI-MIP simulations are compared against observations. The uncertainties among models are quantified by model agreement. Only model agreement >50% is considered to generate reliable projections of floods and water availability and their relationships with climate change. The results show five major points. First, ISI-MIP simulations have acceptable ability in modeling floods and water availability. The spatial patterns of changes in floods and water availability highly depend on the outputs of GCMs. Uncertainties from GCMs/hydrologic models predominate the uncertainties in the wet/dry areas in eastern/northwestern China. Second, the magnitudes of floods throughout China increase during 2070–99 under RCP8.5 relative to those with the same return periods during 1971–2000. The increase rates of larger floods are higher than those of the smaller ones. Third, water availability decreases/increases in southern/northern China under RCP8.5, but changes negligibly under RCP2.6. Fourth, more severe floods in the future are driven by more intense precipitation extremes over China. The negligible change in mean precipitation and the increase in actual evapotranspiration reduce the water availability in southern China. Fifth, model agreements are higher in simulated floods than water availability because increasing precipitation extremes are more consistent among different GCM outputs compared to mean precipitation.