Abstract: Homogenization and similarities of precipitation and flow regimes across China are thoroughly investigated using Gini coefficient analysis method and the Analysis Of Similarity (ANOSIM) technique, respectively based on daily precipitation data from 554 meteorological stations and monthly streamflow data from 370 hydrological stations covering the period of 1960–2000. The results indicate that: (1) Homogenization of precipitation regimes is increasing from the northwest to the southeast China. However, different spatial patterns of homogenization of flow regions are identified. Spatially, lower homogenization of flow regimes is detected in the northeast China and higher homogenization of flow regimes in the central and southeast China. Temporally, flow regimes during 1961–2000 are characterized mainly by increasing homogenization, and it is particularly true after 1980; (2) precipitation regimes during 1961–2000 are characterized by decreasing dissimilarities. Larger areas of China are characterized by decreasing dissimilarities of precipitation regimes during 1980–2000 when compared to those during 1961–1980, which should be due to increasing precipitation concentration and intensifying precipitation regimes in recent years; (3) distinctly dissimilar precipitation and flow regimes can be identified between geographically separate river basins. Interregional similarities of flow regimes are enhancing after 1980 when compared to those before 1980 though interregional similarities of precipitation regimes are not changed much; and (4) spatial mismatch is evident in terms of spatial range and changing degree of flow and precipitation regimes. Roughly spatial match can be observed between changes of flow and precipitation indicates and it is particularly the case for precipitation and flow changes in dry season such as winter in China. However, influences of human activities and precipitation changes on streamflow are varying as for specific river basins, such as the Yangtze and the Yellow River basins. Damming-induced fragmentation of river basins is the major cause behind higher homogenization of flow regimes. Thus, human interferences in hydrological processes via damming and construction of reservoirs greatly alter streamflow vs. precipitation relations. The results of this study provide theoretical and practical grounds for management and planning of water resources at basin or interbasin scales under the influences of human activities and climate changes.