Abstract: The assumption of stationarity of annual peak flood (APF) records at 28 hydrological stations across the Pearl River basin, China, is tested. Abrupt changes in mean and variance are tested using the Pettitt technique and the Loess method. Trends of APFs are analyzed using the Mann–Kendall method and the Spearman technique. And then the stationarity of the APF series is further investigated by GAMLSS models and long-term persistence. Results indicate that: (1) abrupt changes in mean and variance have similar influences on the changing properties of APFs, such as stationarity. Abrupt changes in mean and variance are only field significant in the East River basin; (2) the change points have a considerable impact on the detection of trends, and these may be attributed to the fact that a abrupt increase or decrease in mean values will affect the trend variations. Besides, for the APF series being free of change points and trend, the GAMLSS models also corroborate stationarity of the APF series; (3) the nonstationarity in the Pearl River basin is mainly due to the existence of the change point. However, the APF series with change points in mean and/or variance are also characterized by long-term persistence, and thus it is infeasible to assert that the abrupt behaviors and/or trends of the APF series are the result of human activities or long-term persistence, especially in the East River basin. Results of this study will provide information for management of water resources and design of hydraulic facilities in the Pearl River basin in a changing environment.